|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups.
|
27902482 |
2017 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
GWASDB |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
BEFREE |
In addition, the allelic (CD: p < 0.00001, OR = 1.34; UC: p < 0.00001, OR = 1.22) and dominant models (CD: p = 0.002, OR = 1.39; UC: p = 0.01, OR = 1.29), but not the recessive model of rs10889677 polymorphism significantly increase the risk of CD and UC (p > 0.05).
|
31728561 |
2020 |
|
Ulcerative Colitis
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Thyroid associated opthalmopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
The C allele of rs10889677 was present in 78.6% of GO patients and 64.5% of controls (P=1.3x10(-4); OR=2.03), and the CC genotype was also significantly increased in GO patients vs. controls (62.1 and 41.0%, respectively; P=1.4x10(-4); OR=2.36).
|
18073300 |
2008 |
|
Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNP sites (rs10889677 and rs2201841 of interleukin [IL]-23R, and rs2243248 of IL-4) showed significant correlation with the occurrence of SAPHO syndrome in additive and dominant genetic models, while rs7517847 of IL-23R showed substantial correlation with SAPHO in the dominant genetic model.
|
31701644 |
2019 |
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated whether the association between IL23R +2199 rs10889677 and gastric cancer risk varies by clinical characteristics and the prognostic value of the polymorphism in a case-control study.
|
20863779 |
2011 |
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that CT (OR<sub>adj</sub> = 0.59; 95% CI: 0.44-0.79), CT + TT (OR<sub>adj</sub> = 0.58; 95% CI: 0.43-0.77) genotypes, and T allele (OR<sub>adj</sub> = 0.77; 95% CI: 0.47-0.80) of rs3748067 reduced GC risk; the rs10889677 CC genotype (OR<sub>adj</sub> = 2.22; 95% CI: 1.27-3.87) and C allele (OR<sub>adj</sub> = 1.24; 95% CI: 1.02-1.52) increased GC risk.
|
29118466 |
2017 |
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The <i>let-7</i>-related polymorphism rs3811463 in <i>LIN28A</i> is associated with the susceptibility to gastric cancer and the <i>let-7</i>-related polymorphism rs10889677 in <i>IL23R</i> is associated with the prognosis of gastric cancer.
|
30833806 |
2019 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
A hospital-based case-control study of 684 ESCC patients and 1064 healthy controls was performed to assess the association between four previous reported IL-23R genotypes (rs6682925, rs6683039, rs1884444 and rs10889677) and ESCC risk.
|
24586528 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings indicated that rs10889677A>C polymorphism in IL-23R may play a protective role in mediating the risk of ESCC.
|
24586528 |
2014 |
|
Solid Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings demonstrated that the IL-23R rs10889677</span> genetic variant might play an important part during malignant transformation of multiple solid tumors.
|
24278297 |
2013 |
|
Sjogren's Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In our study, we genotyped groups of patients with AS (n = 206), SS (n = 156) and healthy controls (n = 235) for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, rs11209026, rs10489629, rs7517847 and rs7530511 variants using PCR-RFLP methods.
|
19522770 |
2009 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote.
|
21717520 |
2012 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed that bearing these alleles represent risk for the development of rheumatoid arthritis (chi(2) = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and chi(2) = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841).
|
17606463 |
2008 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data emphasise that the AA genotype of rs11209026 (Arg381Gln) was significantly associated with RA patients compared to the controls (P value=0.001).We did not find any significant association between either rs2201841 or rs10889677 and the development of rheumatoid arthritis (P value=1.000 & 0.562 respectively).
|
25858864 |
2015 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk for Crohn's disease and ankylosing spondylitis, while rs1343151 had a protective effect in both of these diseases, and the rs2201841 and rs10889677 SNPs showed susceptibility nature for rheumatoid arthritis.
|
23054009 |
2013 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Lack of association between rheumatoid arthritis and genetic variants rs10889677, rs11209026 and rs2201841 of IL-23R gene.
|
29370888 |
2018 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Knowing this, the aim of this study was to investigate the association of +2199 A/C IL-23R (rs10889677), -197 G/A IL-17A (rs2275913), and +7488 A/G IL-17F (rs763780) gene polymorphisms with RA susceptibility and clinical features in a Brazilian population.
|
28547498 |
2017 |
|
Rheumatic Heart Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the IL17F (rs763780) and IL23R (rs10889677) polymorphisms did not show any association with RHD.
|
29985710 |
2018 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not find any significant association between IL-23R (rs10889677 and rs11805303) gene polymorphisms and psoriasis risk in South Indian Tamil population.
|
26472011 |
2016 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the C allele of the rs10889677A>C polymorphism in the 3'-untranslated region of IL-23R was inversely associated with risk of multiple types of cancer, including breast cancer, lung cancer and nasopharyngeal carcinoma.
|
23042301 |
2012 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, no evidence of a relationship between IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) and cancer risk was found in the overall population.Our meta-analysis provides no evidence supporting a global association of IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) with the risk of cancer.
|
26717375 |
2015 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our findings indicate that the IL-23R rs10889677A>C polymorphism may influence T-cell proliferation, resulting in changes in the levels of Tregs in vivo and modifying cancer susceptibility.
|
23042301 |
2012 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Significant associations between rs6682925 or rs10889677 polymorphism and cancer risk were found (OR=1.11, 95% CI=1.03-1.21, P=0.007; or OR=0.85, 95% CI=0.71-0.92, P=0.001).
|
24076440 |
2014 |